Neural regulation of ejaculation

In their article the authors try to understand the neurophysiological mechanisms of ejaculatory behavior as it is crucial for the treatment of male sexual dysfunction, including premature ejaculation ( PE ) . In previous studies researches found evidence that a population of lumbar spinothalamic (LSt) cells may play a role in the regulation of the ejaculatory response. Subsequent to ejaculation,  these cells show signs of activation that are highly correlated with ejaculatory behavior and also absent following the expression of other components of sexual behavior, such as mounts or intromissions. The review published by Young et al. is intended to summarize what has currently been revealed regarding the role of LSt cells in the regulation and generation of ejaculatory behavior, and also to discuss the direction of future behavioral investigations. The authors present data derived from analysis of numerous recent articles detailing the delineation of anatomical and physiological correlates of sexual behavior, as well as numerous literature searches using the National Library of Medicine PubMed Services. The authors concluded that LSt cells appear to play a vital role in the generation and regulation of ejaculatory behavior. Additional elucidation of this "ejaculation generator" could prove invaluable for the future treatment of male sexual dysfunction and Premature Ejaculation ( PE ) . Studies are currently in progress to further reveal the precise function of these cells and mechanisms of action through which they operate.

PEhomepage editorial team note: Recently, Priligy ^TM ( dapoxetine ) was approved for the treatment of Premature Ejaculation. Priligy ^TM is a SSRI and it is not completely clear what is the mechanism of its action. It will be interesting to investigate SSRI effect on these LSt cells.

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